www-vendruscolo.ch.cam.ac.uk

The Vendruscolo Laboratory

A rational design strategy for the selective activity enhancement of a molecular chaperone toward a target substrate. Biochemistry (2015). Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins Proc. Natl. Acad. Sci. USA (2015). Structure of a low-population intermediate state in the release of an enzyme product. eLife (2015). A molecular chaperone breaks the catalytic cycle that generates toxic Abeta oligomers. Nat. Struct. Mol. Biol. (2015).

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A rational design strategy for the selective activity enhancement of a molecular chaperone toward a target substrate. Biochemistry (2015). Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins Proc. Natl. Acad. Sci. USA (2015). Structure of a low-population intermediate state in the release of an enzyme product. eLife (2015). A molecular chaperone breaks the catalytic cycle that generates toxic Abeta oligomers. Nat. Struct. Mol. Biol. (2015).

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The Vendruscolo Laboratory | www-vendruscolo.ch.cam.ac.uk Reviews

https://www-vendruscolo.ch.cam.ac.uk

A rational design strategy for the selective activity enhancement of a molecular chaperone toward a target substrate. Biochemistry (2015). Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins Proc. Natl. Acad. Sci. USA (2015). Structure of a low-population intermediate state in the release of an enzyme product. eLife (2015). A molecular chaperone breaks the catalytic cycle that generates toxic Abeta oligomers. Nat. Struct. Mol. Biol. (2015).

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www-vendruscolo.ch.cam.ac.uk

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The Vendruscolo Laboratory

http://www-vendruscolo.ch.cam.ac.uk/index.html

Centre for Misfolding Diseases. Our research is aimed at understanding the molecular origins of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, and at opening in this way novel opportunities for drug discovery to prevent, delay or treat these conditions. We have set up an interdisciplinary approach that brings together concepts and methods from chemistry, physics, engineering, genetics and medicine, using a combination of in silico, in vitro and in vivo approaches. A rational...

2

The Vendruscolo Laboratory

http://www-vendruscolo.ch.cam.ac.uk/publications.html

Centre for Misfolding Diseases. P Flagmeier, G. Meisl, M. Vendruscolo, T. P. J. Knowles, C. M. Dobson, A. K. Buell and C. Galvagnion. Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of alpha-synuclein aggregation. Proc Natl. Acad. Sci. USA, in press. G Fusco, T. Pape, P. Mahou, P. Arosio, A. Rita Costa, G. Kaminski-Schierle, M. Vendruscolo, G. Veglia, C. M. Dobson and A. De Simone. Structural basis of synaptic vesicle assembly promoted by alpha-synuclein.

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The Vendruscolo Laboratory

http://www-vendruscolo.ch.cam.ac.uk/people.html

Centre for Misfolding Diseases. Postdoc (faa25@cam.ac.uk). Postdoc (mb2006@cam.ac.uk). PhD Student (anb39@cam.ac.uk). Postdoc (cc536@cam.ac.uk). MPhil Student (skrc2@cam.ac.uk). Postdoc (fe237@cam.ac.uk). PhD Student (rf389@cam.ac.uk). PhD Student (bf267@cam.ac.uk). Visiting Professor (stefano.gianni@uniroma1.it). PhD Student (pj291@cam.ac.uk). Postdoc (pk397@cam.ac.uk). Postdoc (jh884@cam.ac.uk). MPhil Student (gthh3@cam.ac.uk). Postdoc (gp388@cam.ac.uk). PhD Student (ps589@cam.ac.uk).

4

The CamSol method for protein solubility prediction

http://www-vendruscolo.ch.cam.ac.uk/camsolmethod.html

The CamSol solubility score is tested against experimentally determined solubility changes upon mutation from the literature. The testing set contains 56 different protein variants from 19 wild type proteins and includes some antibodies. The bar plot reports the fraction of correctly predicted solubility changes upon mutation using CamSol and two methods of predicting solubility upon over-expression that are SOLpro, and PROSO II. See Reference 1 for details. Identification of self-assembly hotspots.

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Over the years I have created web sites. For both research groups and NGOs. I have also created web sites to collect data for conservation purposes. Here is a list of some of the web sites that I have developed. Otter road-kills in Italy. A web site where data on otters that are found dead are reported in a map. Otter Specialist Group - Otter mortality. A web site, within the Otter Specialist Group. Invasive species in Italy. A web site that provides information on invasive species (in Italian).

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www-vendruscolo.ch.cam.ac.uk

The Vendruscolo Laboratory

A rational design strategy for the selective activity enhancement of a molecular chaperone toward a target substrate. Biochemistry (2015). Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins Proc. Natl. Acad. Sci. USA (2015). Structure of a low-population intermediate state in the release of an enzyme product. eLife (2015). A molecular chaperone breaks the catalytic cycle that generates toxic Abeta oligomers. Nat. Struct. Mol. Biol. (2015).

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