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Our long-term objectives are to understand the genetic pathways that control human hematopoietic stem cells (HSCs) and to determine how changes in these programs lead to generating leukemic stem cells (LSC). By identifying the target pathways involved in these changes we will be able to contribute to the development of targeted therapeutics. An integrated analysis of heterogeneous drug responses in acute myeloid leukemia that enables the discovery of predictive biomarkers. Read more news stories in the.

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Our long-term objectives are to understand the genetic pathways that control human hematopoietic stem cells (HSCs) and to determine how changes in these programs lead to generating leukemic stem cells (LSC). By identifying the target pathways involved in these changes we will be able to contribute to the development of targeted therapeutics. An integrated analysis of heterogeneous drug responses in acute myeloid leukemia that enables the discovery of predictive biomarkers. Read more news stories in the.
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Our long-term objectives are to understand the genetic pathways that control human hematopoietic stem cells (HSCs) and to determine how changes in these programs lead to generating leukemic stem cells (LSC). By identifying the target pathways involved in these changes we will be able to contribute to the development of targeted therapeutics. An integrated analysis of heterogeneous drug responses in acute myeloid leukemia that enables the discovery of predictive biomarkers. Read more news stories in the.

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Our lab have been selected as the 2013 recipient of the Lap-Chee Tsui Publication Award (biomedical research) for our publication Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer, Science 2013; 339 (6119): 543-548 . Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts. The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress. Stem Cells: Genome-Wide Study of Genes That Reg...

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Our long-term objectives are to understand the genetic pathways that control human hematopoietic stem cells (HSCs) and to determine how changes in these programs lead to generating leukemic stem cells (LSC). By identifying the target pathways involved in these changes we will be able to contribute to the development of targeted therapeutics. An integrated analysis of heterogeneous drug responses in acute myeloid leukemia that enables the discovery of predictive biomarkers. Read more news stories in the.

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