brainminds.jp
代表機関（理化学研究所） | 革新的技術による脳機能ネットワークの全容解明プロジェクト
http://brainminds.jp/central/core
人間の高度で複雑な社会性を実現する高次脳機能を担う神経回路を解明するために、従来の 個体個別の認知機能それぞれに対応する脳神経基盤の解析 という研究概念を一新し、人間に近い複雑な社会行動特性を示すマーモセットを用いて 長期間に亘る経時的な社会的群相互作用の時間発展と未知の複合脳神経回路相互作用の探索的解析 を可能にする新しい研究概念を創出し、その行動特性とそれを担う神経回路を同定して長期に亘る活動動態の変容を評価する方法を確立します。 本研究計画は、岡野栄之チーム 慶応 理研 と佐々木えりかチーム 実中研 理研 慶応 と協力して実行します。 現在、アルツハイマー病 AD に対する予防薬 治療薬の前臨床研究には、おもにマウスモデルが使用されています。 遺伝子改変や薬物投与により特定の神経回路、神経伝達機能を変化させることにより作製した様々な病態モデルマーモセットを解析し、ヒト精神 神経疾患へのトランスレータブルな 中間表現型 としてのイメージングバイオマーカーを抽出します。 Cold Spring Harbor Laboratory.
biomed.sci.waseda.ac.jp
早稲田大学 先進理工学部 生命医科学科│教員および研究テーマ紹介
http://www.biomed.sci.waseda.ac.jp/member
とくに、キラリティ 左右性 を有する物質の機能と構造の研究に取り組み、Generalized High Accuracy Universal Polarimeter (G-HAUP)と呼ばれる独自の光学装置を用いて光学活性と円2色性の最先端研究を行っています。 Optical properties of salicylideneaniline microcrystals with photomechanical functions. 先進 Top Runner 先進理工学部 web site. 先進 Top Runner 先進理工学部 web site. Retinoic acid receptor alpha (RARα) induces epithelial-mesenchymal transition(EMT) and promotes cell migration. Identification of the ERBB2-dependent transforming activity of GRB7. 先進 Top Runner 先進理工学部 web site.
brainwindows.wordpress.com
Drosophila visual system | Brain Windows
https://brainwindows.wordpress.com/2012/10/24/drosophila-visual-system
New tools for peering into the brain…. Click-thru for the original resolution of a fellow Janelian’s Nikon Small World 4th place. Prize winner. Ryan Williamson composed the image. Drosophila melanogaster visual system halfway through pupal development, showing retina (gold), photoreceptor axons (blue), and brain (green) (1500x). Laquo; G-CaMP5 is finally published! Genetically-encoded intracellular EM stain for connectomics. Date : October 24, 2012. FlyFashioNaut Star Bear Publications.
brainwindows.wordpress.com
GCaMP6 plasmids at addgene | Brain Windows
https://brainwindows.wordpress.com/2012/11/08/gcamp6-plasmids-at-addgene
New tools for peering into the brain…. GCaMP6 plasmids at addgene. Are on addgene. Three flavors, fast kinetics or big signals. Bigger responses than OGB-1, some are MUCH bigger. The responses to drifting gratings in visual cortex are spectacular. Sorry no pics for now. Hopefully the reviewers will be nice so we can all read about it soon. Still work to be done getting true 1AP resolution when simultaneously imaging large populations of neurons, but for single neuron imaging. From the SfN abstract :.
brainwindows.wordpress.com
Journal Club | Brain Windows
https://brainwindows.wordpress.com/journal-club
New tools for peering into the brain…. Journal Club #5 – In Vivo Inhibition Dynamics. Inhibition has a powerful role shaping the network dynamics of the cortex, but most studies of inhibitory circuitry are done in brain slice or anesthetized animals. In Membrane potential dynamics of GABAergic neurons in barrel cortex of behaving mice. Journal Club #4 – Photoactivatable Transcription. Journal Club #3 – Rodent Secondary Somatosensory Cortex (SII). Journal Club #2 – A brief history of calcium imaging.
brainwindows.wordpress.com
Philosophy | Brain Windows
https://brainwindows.wordpress.com/philosophy
New tools for peering into the brain…. Here is a collection my writings that are of a more philosophical nature. Freedom of Scientific Information. A brief piece on the flow of scientific knowledge and the merits of a open system of information sharing. The Science of Free Will. Prepared remarks for the Unitarian Universalist congregation in my hometown led off by two readings from Hippocrates and David Foster Wallace. The topic? And is well worth the 10 minute reading time. Leave a Reply Cancel reply.
brainwindows.wordpress.com
Code | Brain Windows
https://brainwindows.wordpress.com/code
New tools for peering into the brain…. Leave a Reply Cancel reply. Enter your comment here. Fill in your details below or click an icon to log in:. Address never made public). You are commenting using your WordPress.com account. ( Log Out. You are commenting using your Twitter account. ( Log Out. You are commenting using your Facebook account. ( Log Out. You are commenting using your Google account. ( Log Out. Notify me of new comments via email. Ryohei’s Neuroscience Notes. Blog at WordPress.com.
brainwindows.wordpress.com
Genetically-encoded intracellular EM stain for connectomics | Brain Windows
https://brainwindows.wordpress.com/2012/10/25/genetically-encoded-intracellular-em-stain-for-connectomics
New tools for peering into the brain…. Genetically-encoded intracellular EM stain for connectomics. The field of connectomics. From the Tsien lab, is a genetically-encoded tag that can stain via singlet oxygen generation, but requires light to activate it. In Nature Biotechnology, Alice Ting’s group reports APEX. Laquo; Drosophila visual system. GCaMP6 plasmids at addgene. Date : October 25, 2012. Categories : circuit mapping. Leave a Reply Cancel reply. Enter your comment here. Address never made public).
brainwindows.wordpress.com
BrainStorm | Brain Windows
https://brainwindows.wordpress.com/brainstorm
New tools for peering into the brain…. Project ideas currently under development. BrainStorm 1 : Calcium Memory Sensors. Leave a Reply Cancel reply. Enter your comment here. Fill in your details below or click an icon to log in:. Address never made public). You are commenting using your WordPress.com account. ( Log Out. You are commenting using your Twitter account. ( Log Out. You are commenting using your Facebook account. ( Log Out. You are commenting using your Google account. ( Log Out.
